Cholesterol is converted to pregnenolone by the cytochrome P450 side-chain cleavage enzyme. Identify diseases caused by oversecretion of adrenal catecholamines.Īdrenal steroid hormone synthetic pathway.Describe and integrate the interactions of adrenal medullary and cortical hormones in response to stress.Describe the biologic consequences of sympatho-adrenal medulla activation and identify the target organs or tissues for catecholamine effects along with the receptor types that mediate their actions.Identify the chemical nature of catecholamines and their biosynthesis and metabolic fate.Identify the causes and consequences of oversecretion and undersecretion of glucocorticoids, mineralocorticoids, and adrenal androgens.Describe the regulation of mineralocorticoid secretion and relate this to the regulation of sodium and potassium excretion.Identify the major mineralocorticoids, their biologic actions, and their target organs or tissues.Understand the cellular mechanism of action of adrenal cortical hormones and identify their major physiologic actions, particularly during injury and stress.Describe and contrast the regulation of synthesis and release of the adrenal steroid hormones (glucocorticoids, mineralocorticoids, and androgens) and the consequences of abnormalities in their biosynthetic pathways.Identify the functional anatomy and zones of the adrenal glands and the principal hormones secreted from each zone.
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